Ko ngā tino take o te psoriasis ko ngā āhuatanga ira, te ārai mate, te taiao me ētahi atu āhuatanga, ā, kāore anō kia tino mārama te whanaketanga o tōna mate.
1. Ngā āhuatanga ira
He maha ngā rangahau kua whakaatu he mea nui te pānga o ngā āhuatanga ira ki te whanaketanga o te psoriasis. E 10% ki te 23.8% o ngā tūroro i Haina, ā, e 30% i ngā whenua ke, he hītori whānau tō rātou mō te mate.Ko te tūponotanga o te whānautanga o tētahi tamaiti me te psoriasis he 2% mēnā kāore tētahi o ngā mātua e pāngia ana e te mate, 41% mēnā kei ngā mātua e rua te mate, ā, 14% mēnā kei tētahi o ngā mātua te mate.Kua whakaatuhia e ngā rangahau mō ngā māhanga e pā ana ki te psoriasis, e 72% te tūponotanga o ngā māhanga monozygotic ki te pāngia e te mate i te wā kotahi, ā, e 30% te tūponotanga o ngā māhanga dizygotic ki te pāngia e te mate i te wā kotahi. Neke atu i te 10 ngā mea e kiia nei he wāhi whakaraerae kua tautuhia e pā kaha ana ki te whanaketanga o te psoriasis.
2. Ngā āhuatanga ārai mate
Ko te whakahohenga rerekē o ngā T-lymphocytes me te urunga ki roto i te kiriuhi kiri, te dermis rānei, he āhuatanga nui o te pathophysiology o te psoriasis, e tohu ana i te whai wāhi o te pūnaha ārai mate ki te whanaketanga me te haere whakamua o te mate.Kua whakaatuhia e ngā rangahau hou ko te whakaputanga IL-23 e ngā pūtau dendritic me ētahi atu pūtau whakaatu antigen (APC) ka whakaoho i te rerekētanga me te tipu o ngā lymphocytes T āwhina CD4+, ngā pūtau Th17, me ngā pūtau Th17 pakeke kua wehea ka taea te whakaputa i ngā momo āhuatanga pūtau rite ki te Th17 pērā i te IL-17, IL-21, me te IL-22, e whakaoho ana i te tipu nui o ngā pūtau hanga keratin, i te urupare mumura rānei o ngā pūtau synovial. Nō reira, ko ngā pūtau Th17 me te tuaka IL-23/IL-17 pea te mea nui ki te pathogenesis o te psoriasis.
3. Ngā Take Taiao me ngā Take Pūmua
He mea nui ngā āhuatanga taiao ki te whakaoho, ki te whakanui rānei i te psoriasis, ki te whakaroa rānei i te mate, tae atu ki ngā mate pāwera, te ahotea hinengaro, ngā whanonga kino (hei tauira, te momi hikareti, te waipiro), te whara, me ngā tauhohenga ki ētahi rongoā.Ko te tīmatanga o te pitting psoriasis he mea hono tonu ki te mate streptococcal whakapeka o te korokoro, ā, mā te rongoā ārai mate ka taea te whakapai ake, te whakaiti, te whakakore rānei i ngā whara kiri. Ka taea e te ahotea hinengaro (pēnei i te ahotea, te mate moe, te mahi nui) te puta, te kino ake, te hoki mai anō rānei o te psoriasis, ā, mā te whakamahi i te rongoā whakaaro hinengaro ka taea te whakamama i te mate. Kua kitea anō hoki he nui te horapa o te toto toto tiketike, te mate huka, te hyperlipidemia, te mate uaua coronary, me te mate metabolic syndrome i waenga i ngā tūroro psoriasis.
Wā tuku: Maehe-17-2023
